Managing Antibiotic-Induced Diarrhea FortiFlora® is here to help

Causes of

microbiota

imbalance

Stress

Age

Illness

Diet change

Antibiotics

FortiFlora

Nutritional Supplements

The Dierence is in Our Science

PURINA

PRO PLAN VETERINARY DIETS

Managing Antibiotic-Induced

Diarrhea

FortiFlora

is here to help

Gastrointestinal tract conditions such as diarrhea

are commonly seen in dogs and cats are often

associated with an imbalance in the intestinal

microﬂora. Many factors can negatively aect

the balance of intestinal bacteria. The use of

broad-spectrum antibiotics (commonly used

to treat infections) causes a disturbance in

intestinal microbiota.

SAFETY STUDIES:

REMEMBER - Safety Studies must be conducted on potential probiotics

to prove that the probiotic does not acquire unnatural antibiotic resistance

(i.e. become resistant to the eﬀects of drugs), does not transmit antibiotic

resistance to other microbiota, nor produce harmful products. Stability studies

must prove that the probiotic survives through typical manufacturing,

shipping and storage conditions.

FortiFlora

with probiotic strain SF68

has been shown to improve

poor fecal quality associated with microbiota imbalances, stress,

antibiotic therapy or diet change. This probiotic has been shown to be

safe, stable and eective in promoting normal intestinal health and

balance, as well as promoting a strong immune system.

The Dierence is in the Science

Help dogs and cats with diarrhea improve faster

by pairing Purina

Pro Plan Veterinary Diets

FortiFlora

with antibiotics.

STUDIES:

References:

1. Weese SJ, Martin H. Assessment of commercial probiotic bacterial contents and label accuracy.

Can Vet J 2011:52:43-46

2. Barko PC, McMichael MA, Swanson KS, Williams DA. The Gastrointestinal Microbiome: A Review.

J Vet Intern Med 2018;32:9-25

3. Torres-Henderson C, Summers S, Suchodolshi J, Lappin MR. Eﬀect of Enterococcus Faecium

Strain SF68® on Gastrointestinal Signs and Fecal Microbiome in Cats Administered Amoxicillin-

Clavulanate. Topics in Compan An Med 32 (2017) 104–108

4. Fenimore A, Groshong L, Scorza V, Lappin MR. Evaluation of Enterococcus Faecium SF68®

Supplementation with Metronidazole For the Treament of Nonspeciﬁc Diarrhea in Dogs Housed

in Animal Shelters. J VET INTERN MED. 2012; 26:793

5. Audra Fenimore, DVM, MS, Laura Martin, DVM, Michael R. Lappin, DVM, PhD, DACVIM. Evaluation

of Metronidazole With and Without Enterococcus Faecium SF68® in Shelter Dogs With Diarrhea.

Topics in Compan An Med 32 (2017) 100–103. Topics in Compan An Med 32 (2017) 100–103

Once FortiFlora

enters the GI tract, it promotes

the colonization of good bacteria to help

maintain microbial balance.

Purina trademarks are owned by Société des Produits Nestlé S.A. VET-2011E-FFANTIBIOTIC

†

2018 Veterinary Aitude Study, Impact Vet, Fall 2018

FortiFlora

Nutritional

Supplement and Metronidazole.

Beer Together

n This study showed that it is beneﬁcial to use metronidazole and

Enterococcus faecium SF68

(found only in FortiFlora

) together to

manage dogs with nonspeciﬁc diarrhea. It was shown that dogs given

FortiFlora

in addition to metronidazole showed improvement in just

2.8 days, as oppose to 4.4 days for dogs on metronidazole alone.

n SF68

is not susceptible to metronidazole therefore the 2 agents can

be administered concurrently.

Audra Fenimore, DVM, MS, Laura Martin, DVM, Michael R. Lappin, DVM, PhD, DACVIM

Evaluation of Metronidazole With and Without Enterococcus Faecium SF68® in

Shelter Dogs With Diarrhea. Topics in Compan An Med 32 (2017) 100–103

FortiFlora

Nutritional

Supplement use with

Amoxicillin-Clavulanate

n The results showed administering amoxicillin-clavulanate orally

to cats commonly induces diarrhea and alters the gastrointestinal

microbiome, and that feeding the probiotic SF68

(found only in

FortiFlora

) can lessen some associated clinical abnormalities.

Torres-Henderson C, Summers S, Suchodolshi J, Lappin MR. Eﬀect of Enterococcus

Faecium Strain SF68® on Gastrointestinal Signs and Fecal Microbiome in Cats

Administered Amoxicillin-Clavulanate. Topics in Compan An Med 32 (2017) 104–108

Fast is Good.

Faster is Better.

2.8

DAYS

4.4 DAYS

until diarrhea

improvement

Dogs taking

metronidazole

Dogs taking

metronidazole

plus FortiFlora

until diarrhea

improvement

For more information, visit www.ProPlanVeterinaryDiets.ca or

call us at 1-866-884-VETS (8387). Have a Case consult? We are here

to help. Contact our Canadian Veterinary Nutrition team at

veterinarytechnicalconsults

@purina.nestle.com.

is the

PROBIOTIC

†